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KMID : 0545120130230071041
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Journal of Microbiology and Biotechnology
2013 Volume.23 No. 7 p.1041 ~ p.1045
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Performance of the xTAG® Gastrointestinal Pathogen Panel, a Multiplex Molecular Assay for Simultaneous Detection of Bacterial, Viral, and Parasitic Causes of Infectious Gastroenteritis
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Eric C. Claas
Carey-Ann D. Burnham
Tony Mazzulli
Kate Templeton
Francois Topin
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Abstract
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The xTAG® Gastrointestinal Pathogen Panel (GPP) is a multiplexed molecular test for 15 gastrointestinal pathogens. The sensitivity and specificity of this test were assessed in 901 stool specimens collected from pediatric and adult patients at four clinical sites. A combination of conventional and molecular methods was used as comparator. Sensitivity could be determined for 12 of 15 pathogens and was 94.3% overall. The specificity across all 15 targets was 98.5%. Testing for the pathogen identified was not requested by the physician in 65% of specimens. The simultaneous detection of these 15 pathogens can provide physicians with a more comprehensive assessment of the etiology of diarrheal disease.
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KEYWORD
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Luminex, xTAG GPP, multiplex, gastroenteritis, infectious diarrhea
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